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Turkish Journal of Biology

DOI

-

Abstract

Antibacterial, antifungal and cytotoxic activities of ethanol extract of tuberous roots of Amorphophallus campanulatus were studied. Disc diffusion technique was used to determine in vitro antibacterial and antifungal activities. Cytotoxicity was determined against brine shrimp nauplii. In addition, minimum inhibitory concentration (MIC) was determined using serial dilution technique to determine antibacterial potency. The extract showed significant antibacterial activities against four gram-positive bacteria (Bacillus subtilis, Bacillus megaterium, Staphylococcus aureus, Streptococcus b-haemolyticus) and six gram-negative bacteria (Escherichia coli, Shigella dysenteriae, Shigella sonnei, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi). The MIC values against these bacteria ranged from 16 to 128 µg/ml. The antifungal activity was found weak against the tested fungi. In cytotoxicity determination, LC_{50} of the extract against brine shrimp nauplii was 7.66 µg/ml.

Keywords

Amorphophallus campanulatus, ethanol extract, gram-positive, gram-negative, MIC, cytotoxicity, antifungal activity

First Page

167

Last Page

172

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