We identified and characterized the rat DVL2 gene using bioinformatics. In addition to the structure and chromosomal localization of the rat DVL2 gene, the transcribed and translated protein product of the gene was analyzed in silico. Results showed that the rat DVL2 gene consists of 15 exons and is located on the rat genomic contig WGA1854.3 on chromosome 10. Database searches using the rat DVL2 amino acid sequence as a query showed a number of homologous protein sequences in different species, including M. musculus, P. troglodytes, C. familiaris, H. sapiens, B. taurus, D. rerio, X. laevis, and T. nigroviridis. DAX, PDZ signaling, and DEP-conserved domain structures were identified within the rat DVL2 protein.
Bioinformatics, DVL2, rat genome, Wnt signaling
VARIŞLI, LOKMAN and ÇEN, OSMAN (2007) "Identification and Characterization of the Rat DVL2 Gene Using Bioinformatic Tools," Turkish Journal of Biology: Vol. 31: No. 2, Article 4. Available at: https://journals.tubitak.gov.tr/biology/vol31/iss2/4