The protective effects of \alpha-keto acids on the mutagenicity of H_2O_2 and NaN_3 was investigated in Salmonella typhimurium TA 98, TA 100, TA 102. H_2O_2 (340 µg/plate) was mutagenic to the strains TA 98 and TA 102 while NaN_3 (1.5 µg/plate) was mutagenic only to TA100. The extents of protective effect of pyruvate (220-440 µg/plate) and \alpha-keto glutarate (335-600 µg/plate) against H_2O_2 were observed to be 37%- 65% in TA 98 and TA 102. \alpha-keto acids were ineffective against NaN_3 induced mutagenicity in TA 100. H_2O_2 (340 µg/plate), in the presence of NaN_3 (1.5 µg/plate) and \alpha-keto acids (330-500 µg/plate), was found to be nonmutagenic to the strain TA102. This cross-adaptive response might have been due to the intactness of the DNA repair system in TA 102. The above combination of H_2O_2, NaN_3 and \alpha-keto acids were found to be cytotoxic in TA 98 and TA 100, possibly because these strains carry uvr B mutation causing defect in their DNA repair system.
ÖKSÜZOĞLU, EMİNE (2005) "Effect of \alpha-Keto Acids Against H_2O_2- and NaN_3-Induced Mutagenesis in Different Strains of Salmonella Typhimurium," Turkish Journal of Biology: Vol. 29: No. 3, Article 5. Available at: https://journals.tubitak.gov.tr/biology/vol29/iss3/5