Turkish Journal of Biology




Salivaricin B (SalB) is a protein encoded by Lactobacillus salivarius M7. This protein is insensitive to proteolytic enzymes, such as pepsin, trypsin, and chymotrypsin, but is partially sensitive to proteinase K. SalB is also stable and maintains its activity over a range of pHs, from 3 to 9. SalB was found to be effective against many closely related lactic acid bacteria such as, L. fermentum, L. plantarum, L. acidophilus and distantly related gram-positive bacteria, including Listeria monocytogenes, Streptococcus faecalis, Staphylococcus aureus and Staph. epidermidis. The mode of action of SalB was obviously bactericidal, and death occurs without bacterial lysis. The gene responsible for SalB production in L. salivarius M7 had previously been characterized.

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