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Turkish Journal of Biology

The Histopathologic Effects of Endosulfan on the Mouse Thyroid Gland

Abstract

In the present study, the acute toxic effects of endosulfan on thyroid glands were investigated by light and electron microscopy. Endosulfan (LD30 4.16 mg/kg) was injected intraperitoneally into adult male mice. In the light microscopic studes, it was observed that some of the follicles had been damaged and joined together. Furthermore, colloidal fluids had diffused from follicles and dispersed into connective tissues. Swelling in endoplasmic reticulum sacs, expansion in perinuclear area, pycnotic nuclei and accumulation of heterochromatin were determined by electron microscopy.

DOI

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Keywords

Endosulfan, thyroid, organochlorine insectiside.

First Page

439

Last Page

445

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