A cytoplasmic escapee: desmin is going nuclear

Authors

ECEM KURAL MANGIT
NİLÜFER DÜZ
PERVİN RUKİYE DİNÇER

DOI

10.3906/biy-2107-54

Abstract

It has been a long time since researchers have focused on the cytoskeletal proteins' unconventional functions in the nucleus. Subcellular localization of a protein not only affects its functions but also determines the accessibility for cellular processes. Desmin is a muscle-specific, cytoplasmic intermediate filament protein, the cytoplasmic roles of which are defined. Yet, there is some evidence pointing out nuclear functions for desmin. In silico and wet lab analysis shows that desmin can enter and function in the nucleus. Furthermore, the candidate nuclear partners of desmin support the notion that desmin can serve as a transcriptional regulator inside the nucleus. Uncovering the nuclear functions and partners of desmin will provide a new insight into the biological significance of desmin.

Keywords

Cytoskeleton, intermediate filament, desmin, nucleus, nuclear localization signal, nuclear export signal

First Page

711

Last Page

719

Recommended Citation

MANGIT, ECEM KURAL; DÜZ, NİLÜFER; and DİNÇER, PERVİN RUKİYE (2021) "A cytoplasmic escapee: desmin is going nuclear," Turkish Journal of Biology: Vol. 45: No. 6, Article 6. https://doi.org/10.3906/biy-2107-54
Available at: https://journals.tubitak.gov.tr/biology/vol45/iss6/6