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Turkish Journal of Medical Sciences

Abstract

Background/aim: The aim of our study was to investigate the effectiveness of lumbar stabilization exercises on serum biomarker levels and clinical outcomes in lumbar disc herniation (LDH) patients with and without neurological deficit.

Materials and methods: 40 patients with neurological deficits (WND) and 34 patients without neurological deficits (WOND) diagnosed with LDH were included in this study. The patients WND and WOND were randomized into stabilization exercises (SE) and general exercises (GE) groups. Stabilization exercises or general exercises were applied for six weeks. Serum levels of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6, IL-4, beta-endorphin (BE), anandamide (AEA), and 2-arachidonoylglycerol (2-AG) were measured using the enzyme-linked immunosorbent assay. All patients filled out the Visual Analog Scale, Oswestry Disability Index, Beck Depression Index and Beck Anxiety Index.

Results: In patients WND and WOND, SE did not show any statistically significant difference in relation to TNF-α, IL-1β, IL-6, IL-4, BE, AEA, and 2-AG (p>0.05). There were no statistically significant differences between the SE and GE groups in pain intensity and disability outcomes in patients WND (p>0.05). SE group showed greater reductions in depression and anxiety scores compared to the GE group (p<0.05). In patients WOND, there were no differences in pain, disability, or depression results between the SE and GE groups (p>0.05), whereas the decrease in anxiety score was greater in the SE group (p<0.05).

Conclusion: Our results demonstrate that no effect of lumbar stabilization exercise is seen on circulating levels of TNF-α, IL-1β, IL-6, IL-4, BE, AEA, and 2-AG. Further exercise trials are needed to investigate what type, duration, and intensity of exercise is relevant for biomarkers that may play a role in the immune process.

Author ORCID Identifier

BİRGÜL MORKOÇ: 0000-0002-9491-5978

ONUR AKTAN: 0000-0003-0164-170X

GAMZE SÖNMEZ: 0009-0001-3488-0283

EBRU BODUR: 0000-0001-5829-5487

JALE KARAKAYA: 0000-0002-7222-7875

BAYRAM KAYMAK: 0000-0002-4659-7362

SEVİL BİLGİN: 0000-0003-1597-1312

DOI

10.55730/1300-0144.6004

Keywords

beta-endorphin, cytokines, endocannabinoids, exercise, Intervertebral disc herniation, physical therapy

First Page

572

Last Page

584

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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