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Turkish Journal of Medical Sciences

Abstract

Background/aim: The objective of this study was to establish the oxidative stress determiners as a total oxidative state (TOS), total antioxidative state (TAS), paraoxonase (PON) activity, oxidative stress index (OSI), and thiol/disulfide levels before and after 6 months of immunomodulator therapy in patients who were diagnosed according to the revised McDonald Criteria.

Materials and methods: Thirty-nine patients were included in our study who were diagnosed according to the revised McDonald Criteria, approved to participate in the study, and had been treated in the neurology inpatient clinic or presented in the neurology outpatient clinic of Ankara Yıldırım Beyazıt University Atatürk Training and Research Hospital. Blood samples were collected from patients before treatment and six months after treatment. The venous blood samples of the patients were evaluated for routine biochemical tests, TOS, TAS, PON activity, OSI, and thiol/disulfide levels.

Results: The oxidative stress parameter levels of blood samples obtained before and after 6 months of the treatment were compared. The blood samples obtained after 6 months of therapy exhibited statistically significant results, including elevated levels of native thiol/total thiol (SH/SH+SS), PON, and TAS (p = 0.001). No significant relation was observed between the duration of disease, sex, used therapy agents, and oxidative stress parameters.

Conclusion: In this study, we determined that TOS and OSI, which are indicators of oxidative stress, and TAS and PON, which exhibit antioxidative activity, can be employed to evaluate the therapy response. Additionally, we found that immunomodulator therapies canexhibit a protective effect, as evidenced by a reduction in oxidative stress indicators.

Author ORCID Identifier

EMEL BAŞAR: 0000-0003-0992-9767

HASAN BAYINDIR: 0000-0002-9260-2230

HATİCE KÖMÜRCÜ: 0000-0002-8371-2913

EBRU DİRİK: 0000-0002-3454-1564

ÖMER ANLAR: 0000-0002-6948-2090

ÖZCAN EREL: 0000-0002-2996-3236

DOI

10.55730/1300-0144.5983

Keywords

immunomodulatory therapy, Multiple sclerosis, oksidative stress

First Page

398

Last Page

403

Publisher

Scientific and Technological Research Council of Türkiye (TUBITAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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