Turkish Journal of Medical Sciences
Abstract
Background/aim: Epithelial ovarian cancer is the second most prevalent type of gynecological cancer. We aimed to investigate prognostic factors related to survival in patient with 2014 FIGO stage IIIC high-grade serous ovarian cancer (HGSOC).
Materials and methods: Two hundred fifty eight patients were evaluated retrospectively. The absence of a visible tumor was determined as maximum cytoreduction, and a residual tumor size of 1 cm or less was determined as optimal cytoreduction. Patients who underwent cytoreduction followed by a combination of platinum and taxane adjuvant chemotherapy were included. Exclusion criteria for the study were patients taking neoadjuvant chemotherapy and those with suboptimal surgery.
Results: Optimal cytoreduction was performed in 107 and maximal cytoreduction was performed in 151 patients. The five-year PFS rate was 27% and the five-year DSS rate was 76%. While high ascites volume and optimal cytoreduction were identified as independent prognostic factors for disease failure, only optimal cytoreduction was an independent prognostic factor for survival.
Conclusion: The maximal cytoreduction is improves PFS and DSS in patients with 2014 FIGO stage IIIC HGSOC as our study results. Therefore, maximum surgical effort and radical cytoreductive procedures should be performed.
Author ORCID Identifier
MEHMET ÜNSAL: 0000-0002-9920-6804
MELTEM YÜCESOY: 0000-0002-5448-8908
OKAN OKTAR: 0000-0002-9696-7886
YEŞİM UÇAR: 0000-0002-1957-4202
GÜLŞAH TİRYAKİ GÜNER: 0000-0003-4543-1763
OKAN AYTEKİN: 0000-0002-6430-4607
A.ALP TOKALIOĞLU: 0000-0002-1776-2744
HANDE ESRA KOCA YILDIRIM: 0000-0002-3715-9424
FATİH KILIÇ: 0000-0002-7333-4883
BURAK ERSAK: 0000-0003-3301-062X
CANER ÇAKIR: 0000-0003-2559-9104
DİLEK YÜKSEL: 0000-0002-2366-8412
ÇİĞDEM KILIÇ: 0000-0002-4433-8068
SEVGİ KOÇ: 0000-0002-1703-0690
GÜNSU KİMYON CÖMERT: 0000-0003-0178-4196
ÖZLEM MORALOĞLU TEKİN: 0000-0001-8167-3837
YAPRAK ENGİN ÜSTÜN: 0000-0002-1011-3848
TANER TURAN: 0000-0001-8120-1143
DOI
10.55730/1300-0144.5980
Keywords
cytoreduction, high-grade serous ovarian cancer, Stage IIIC, survival
First Page
368
Last Page
376
Publisher
Scientific and Technological Research Council of Türkiye (TUBITAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
ÜNSAL, MEHMET; YÜCESOY, MELTEM; OKTAR, OKAN; UÇAR, YEŞİM; TİRYAKİ GÜNER, GÜLŞAH; AYTEKİN, OKAN; TOKALIOĞLU, A.ALP; KOCA YILDIRIM, HANDE ESRA; KILIÇ, FATİH; ERSAK, BURAK; ÇAKIR, CANER; YÜKSEL, DİLEK; KILIÇ, ÇİĞDEM; KOÇ, SEVGİ; KİMYON CÖMERT, GÜNSU; MORALOĞLU TEKİN, ÖZLEM; ENGİN ÜSTÜN, YAPRAK; and TURAN, TANER
(2025)
"Survival of patients with 2014 FIGO stage IIIC high-grade serous ovarian cancer who treated with platin-based adjuvant chemotherapy,"
Turkish Journal of Medical Sciences: Vol. 55:
No.
2, Article 4.
https://doi.org/10.55730/1300-0144.5980
Available at:
https://journals.tubitak.gov.tr/medical/vol55/iss2/4
