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Turkish Journal of Medical Sciences

Abstract

Background/aim: Statins are known to display pleiotropic effects on the vascular system, beyond their lipid-lowering properties. Studieson isolated vascular preparations have demonstrated their acute relaxant effects on vascular tone. Considering the increased evidence inregard to the contribution of perivascular adipose tissue (PVAT) in the regulation of vascular homeostasis, we aimed to investigate thepossible modulatory role of PVAT in the vascular effects of atorvastatin and rosuvastatin in isolated rat aorta.

Materials and methods: Thoracic aortas isolated from young male Wistar rats were divided into two groups: rings with intact PVAT(+) and rings without PVAT (-), and then mounted in an isolated organ bath system. Rat aortic rings were standardized with potassiumchloride (KCl, 40 mM), and then endothelium-dependent relaxation responses were checked by acetylcholine (Ach, 10–7–10–4 M).The concentration-dependent (10–7–10–4 M) effects of atorvastatin and rosuvastatin were studied on rat aortic rings precontractedsubmaximally with phenylephrine (Phe, 10–6–3 × 10–5 M). In addition, endothelium-independent relaxation responses were evaluatedby sodium nitroprusside (SNP, 10–6 M) at the end of each experiment.

Results: Rat aortic rings with intact PVAT (+) and without PVAT (-) displayed similar endothelium-dependent and -independentrelaxations to Ach and SNP, respectively. Increasing concentrations (10–7–10–4 M) of atorvastatin and rosuvastatin directly relaxed theaortic rings with and without PVAT. The maximum relaxant effects of rosuvastatin was found significantly greater than atorvastatin.

Conclusion: The current study demonstrated that atorvastatin and rosuvastatin displayed prominent relaxations in rat aortic rings withintact PVAT (+) and without PVAT (-). Notably, rosuvastatin produced a greater vasorelaxant effect compared to atorvastatin in rataortic rings with and without PVAT. Current study provides a novel evidence that PVAT does not significantly influence statin-mediatedvasorelaxation under physiological conditions.

Author ORCID Identifier

DENİZ KALELİ DURMAN: 0000-0002-8669-7480

MERYEM ARAS: 0000-0002-5926-0953

GÜLSÜM RUVEYDA AKTAŞ: 0000-0002-6671-4239

BİRSEL SÖNMEZ UYDEŞ DOĞAN: 0000-0002-6729-8150

DOI

10.55730/1300-0144.5996

Keywords

Atorvastatin, perivascular adipose tissue, rosuvastatin, vascular relaxation

First Page

518

Last Page

524

Publisher

Scientific and Technological Research Council of Türkiye (TUBITAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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