Turkish Journal of Medical Sciences
Abstract
Background/aim: Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening severe cutaneous drug hypersensitivity reactions. The aim of our study was to evaluate the clinical features of pediatric patients diagnosed with SJS, TEN or SJS/TEN overlap and to examine treatment modalities.
Materials and methods: Patients aged 0–18 years who were followed up with SJS, TEN or SJS/TEN overlap at Ankara Bilkent City Hospital between August 2019 and January 2024 were retrospectively analyzed.
Results: Twelve patients who met the inclusion criteria were included in the study. Five of the patients had SJS, four had SJS/TEN overlap, and three had TEN. Eight of the patients were female, and the median age at presentation was 10.5 (IQR:6–16) years. Ten of the patients had a history of drug use. Eight patients had antibiotics, two had proton pump inhibitors, two had allopurinol, and two had antiepileptic (lamotrigine and valproic acid) use. All 12 patients received IVIG and systemic steroid therapy. Three TEN and four SJS/ TEN overlap patients received cyclosporine. Two TEN patients underwent plasmapheresis. The most common long-term sequelae were dermatological sequelae.
Conclusion: SJS/TEN patients should be monitored with a multidisciplinary approach, and if necessary, in the burn intensive care unit. Primary treatment is supportive care. Early initiation of cyclosporine may have a positive effect on the prognosis in patients with SJS/ TEN overlap and TEN.
Author ORCID Identifier
FUNDA AYTEKİN GÜVENİR: 0000-0002-2703-8055
VİLDAN SELİN ÇAYHAN: 0000-0002-6043-5642
SELMAN KÜRŞAT BALCI: 0009-0001-9443-6010
RAGIP DERE: 0000-0003-2218-5854
HATİCE IRMAK ÇELİK: 0009-0009-5035-0870
SERHAT EMEKSİZ: 0000-0002-8951-4774
AHMET SELMANOĞLU: 0000-0002-6748-7330
ZEYNEP ŞENGÜL EMEKSİZ: 0000-0001-7648-0352
EMRAH ŞENEL: 0000-0002-0383-4559
EMİNE DİBEK MISIRLIOĞLU: 0000-0002-3241-2005
DOI
10.55730/1300-0144.5990
Keywords
drug hypersensitivity, Steven Johnson syndrome, toxic epidermal necrolysis
First Page
461
Last Page
469
Publisher
Scientific and Technological Research Council of Türkiye (TUBITAK)
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
AYTEKİN GÜVENİR, FUNDA; ÇAYHAN, VİLDAN SELİN; BALCI, SELMAN KÜRŞAT; DERE, RAGIP; ÇELİK, HATİCE IRMAK; EMEKSİZ, SERHAT; SELMANOĞLU, AHMET; ŞENGÜL EMEKSİZ, ZEYNEP; ŞENEL, EMRAH; and DİBEK MISIRLIOĞLU, EMİNE
(2025)
"Evaluation of clinical features and treatment modality of pediatric patients with Steven Johnson syndrome/toxic epidermal necrolysis: a single-center experience,"
Turkish Journal of Medical Sciences: Vol. 55:
No.
2, Article 14.
https://doi.org/10.55730/1300-0144.5990
Available at:
https://journals.tubitak.gov.tr/medical/vol55/iss2/14