Authors: Mahmut BASOĞLU, Ahmet BALIK, Ahmet KIZILTUNÇ, Fatih AKÇAY, Selçuk Sabri ATAMANALP
Abstract: To determine serum D(-)-lactate and NO levels in patients with acute mesenteric ischemia. 22 patients (12 with acute mesenteric ischemia, 10 with bowel obstruction) and 12 control patients who were operated due to goitre. Serum D(-)-lactate and NO levels in acute mesenteric ischemia cases compared to small bowel obstruction cases and control patients. Increased serum D(-)-lactate and NO levels in serum levels of ischemic bowel were found to be significantly increased compared to both the cases with small bowel obstruction and control subjects (for D(-)-lactate: p<0.01, p<0.0001; for NO p<0.01, p<0.0001, respectively). Significant correlations between serum D(-)-lactate and NO levels in both acute mesenteric ischemia and small bowel obstruction group (r=0.506, p<0.05, and r=0.692, p<0.05, respectively). The sensitivity and the specificity of the D(-)-lactate assay were 75% and 90%, respectively. The sensitivity and the specificity of NO assay were 83% and 80% respectively. The positive predictive values of the D(-)-lactate and NO were 81% and 71%, respectively. Determination of serum D(-)-lactate and NO levels may be helpful in the diagnosis of difficult acute mesenteric ischemia cases.
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