The Importance of Creatine Phosphokinase (CPK) and Lactate Dehydrogenase (LDH) in the Early Diagnosis of Testicular Torsion

Authors: M. Ramazan ŞEKEROĞLU, Mehmet TARAKÇIOĞLU, Sabahattin AYDIN, Selim TOPAL, Öner ODABAS, Yüksel YILMAZ, Mehmet KARA

Abstract: We aimed to reveal the value of serum CPK and LDH levels in he early diagnosis of testicular tortion in this study. 15 adult male New Zealand rabbits were divided into 2 groups. The first group included 7 animals that experienced sham operation and approved as control animals. In the second group (n=8), the left testes were just twisted 720 degrees and fixed by a transmesorchial suture like Ryan described. Blood samples were obtained by venapuncture at 0, 4, 8, 24 hours and 4 weeks in each group; creatine phosphokinase (CPK) and lactate de-hydrogenase (LDH) were determined. There was slight increase in LDH level in the second group but not statistically significant (p>0.05). On the other hand, significant increase in CPK levels (p>0.05) in 4 hours af-ter torsion were seen (mean 6297±2012 compared to the level in the first sample, 2768±982). CPK tended to decrease after 8 hours (mean 4459±1867). No significant alterations were noted in both enzyme levels in those having sham operation (p>0.05). Thus, determination of serum CPK may be an auxiliary alternative in the diagnosis of testicular torsion.

Keywords: Testicular torsion, creatine phosphokinase, lactate dehydrogenase.

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