Histologic Evaluation in Patients with Benign Prostatic Hyperplasia Treated with Finasteride and Surgery Alone

Authors: Özkan POLAT, Osman GÜL, İsa ÖZBEY, Cemal GÜNDOĞDU, Yılmaz BAYRAKTAR

Abstract: In this study, we compared stroma, epithelium, glandular lumen, smooth muscle hyperplasia, inflammation and fibrous components in benign prostatic hyperplasia (BPH) tissue between the group undergone surgery only and the group who had taken finasteride (5 alpha-reductase inhibitor) prior to surgical treatment. Prostate adenomas were obtained from both 12 patients administered finasteride for six months prior to surgical treatment and those of 11 patients undergone only surgical treatment. The histological evaluation were performed quantitatively by planimetry. The mean epithelium ratio in the group administered 5 alpha-reductase inhibitor prior to surgery lessened approximately twofold compared to the other group's. In conclusion, morphometric analysis may have an indicative role in determining alternative pharmacotherapies for BPH.

Keywords: 5 alpha-reductase inhibitor, morphometric analysis, Histology of benign prostatic hyperplasia.

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