Serum Levels of Lipids, Lipoproteins and Apolipoproteins in Patients with Coronary Artery Disease Documented by Angiography

Authors: Abdurrahim KOÇYİĞİT, İdris AKKUS, Hüseyin VURAL, Hasan GÖK, 0sman ÇAĞLAYAN, Bilal DURMUŞ, Mehmet ÇELİK, Elif MENEKŞE

Abstract: Serum Triglyceride (TG), total cholesterol (TC), phospholipid (PL), Apo A-I, Apo B, lipoprotein (a) (Lp(a)), high-density lipoprotein cholesterol (HDL-C,HDL2-C, HDL3-C), low-density lipoprotein cholesterol (LDL-C) and free cholesterol (FC) levels of 108 subjects with and without coronary artery disease (CAD) documented by coronary angiography were investigated. Subjects were classified as normal and patients with CAD according to degree of vascular stenosis. Those with 50% stenosis in at least one major coronary artery branch were referred as patients with CAD. Patients consisted of 27 women aged 38-73 years and 44 men aged 31-72 years. Controls were 20 women aged 38-77 years and 17 men aged 38-77 years. Men with CAD had significantly higher plasma Lp(a), TC and LDL-C levels than the male controls. They also had significantly lower levels of Apo A-I, HDL-C and HDL2-C. Also, ratios of Apo B/Apo A-I and LDL-C/HDL-C were higher, whereas HDL2-C/HDL-C, HDL-C,TC and HDL2-C/HDL3-C ratios were lower than those of controls. On the other hand plasma Lp(a), Apo B, TC and FC levels of the women with CAD were significantly higher whereas HDL2-C level was lower compared to the values of the female controls. Ratios of Apo B/Apo A-I and LDL-C/HDL-C were significantly higher, HDL2-C/HDL-C and HDL2-C and HDL2-C/HDL3-C ratio were lower than those of female controls. We concluded that Lp(a) is an independent risk factor for CAD and HDL2-C and HDL2-C/HDL3-C ratio are the best indicators of CAD both in men and women.

Keywords: Coronary artery disease, coronary angiography, lipids, lipoproteins, apolipoproteins.