•  
  •  
 

Turkish Journal of Chemistry

Abstract

The in-situ generation of the Vilsmeier-Haack complex was studied by combining Fe3O4@SiO2@CS@POCl2-x with with N,N-dimethylformamide (DMF), demonstrating remarkable efficiency and regioselectivity in transforming epoxides into β-bromoformates. The reported yields were notably high and were achieved under mild reaction conditions. Interestingly, the removal of DMF led to the synthesis of vic-dihalide compounds. The product of this transformation depended on the specific details of how the experiment was done, highlighting how sensitive the process is to different ways of conducting the experiment. The use of a magnetic core-shell catalyst, Fe3O4@SiO2@CS@POCl2-x, facilitates a straightforward work-up procedure, simplifying the isolation of the desired products. Furthermore, the reactions were conducted under clean and neutral conditions, contributing to their environmentally friendly nature.

Author ORCID Identifier

FARZANEH EBRAHIMZADEH: 0000-0001-5825-7288

DOI

10.55730/1300-0527.3717

Keywords

Magnetic nanocatalyst, Vilsmeier-Haack complex, β-bromoformates epoxide, bromide, core-shell structure

First Page

133

Last Page

142

Publisher

Scientific and Technological Research Council of Türkiye (TUBITAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Download

Share

COinS