Turkish Journal of Chemistry
Abstract
Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
DOI
10.3906/kim-0810-50
Keywords
Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.
First Page
209
Last Page
214
Recommended Citation
RAZA, A. R (2009). A Mild Method for the Cleavage of Ketals Using IBX. Turkish Journal of Chemistry 33 (2): 209-214. https://doi.org/10.3906/kim-0810-50