Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.
RAZA, ABDUL RAUF
"A Mild Method for the Cleavage of Ketals Using IBX,"
Turkish Journal of Chemistry: Vol. 33:
2, Article 3.
Available at: https://journals.tubitak.gov.tr/chem/vol33/iss2/3