Abstract

Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.

DOI

10.3906/kim-0810-50

Keywords

Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.

First Page

209

Last Page

214

Recommended Citation

RAZA, A. R (2009). A Mild Method for the Cleavage of Ketals Using IBX. Turkish Journal of Chemistry 33 (2): 209-214. https://doi.org/10.3906/kim-0810-50

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