Authors: ÖZTEKİN ALGÜL, BERRİN ÖZÇELİK, UFUK ABBASOĞLU, FATMA GÜMÜŞ
Abstract: Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and ^1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.
Keywords: Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test
Full Text: PDF