Synthesis and characterization of novel benzovesamicol analogs


Abstract: Three new racemic vesamicol analogs were successfully prepared in good yields and high purity. All compounds were characterized by both IR and NMR spectroscopy. Compounds (\pm)-5 and (\pm)-6 showed a moderate lipophilicity compared with reference compounds IBVM and DRC140, respectively. However, the lipophilicity of DRC140 and (\pm)-9 showed very similar behaviors.

Keywords: Benzovesamicol, ethylenedicysteine, vesicular acetylcholine transporter

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