Authors: DORUK ALTIOK, ELİF ZEYNEP SAVCI, BÜŞRA ÖZKARA, KAMİL ALKAN, DİLARA SULTAN NAMDAR, GİZEM TUNÇER, BUĞRAHAN REGAİP KILINÇ, EVREN SUİÇMEZ, GÜNEYSU ÇETİN, SİNAN ÜNAL, BEYZA DÖNMÜŞ, ZEYNEP YAĞMUR KARAGÜLLEOĞLU, DİLRÜBA BEYZA UNCUOĞLU, CANSU TEKELİ, HANİFE AYŞEGÜL MENDİ, VAHDİ UMUT BENGİ, GÜLDANE CENGİZ SEVAL, PELİN KILIÇ, EVRİM GÜNEŞ ALTUNTAŞ, DEVRİM DEMİR DORA
Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.
Keywords: Angiotensin-converting enzyme 2 (ACE2), host genetics, polymorphisms, SARS-CoV-2, toll-like receptors (TLR), transmembrane serine protease 2 (TMPRSS2)
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