The use of Sodium Carboxymethylcellulose to Prevent Intraabdominal Adhesions in Rabbits


Abstract: The purpose of the study was to evaluate the effect of a 1% sodium carboxymethylcellulose (SCMC) solution on the prevention of experimentally induced intraabdominal adhesions in rabbits. Thirty rabbits were used and divided into two equal groups. In all rabbits in both groups, ventral midline laparotomies and serosal abrasions on the caecum were performed. In the treatment group, a solution of SCMC and in the control group a NaCI solution were infused into the abdominal cavity before and after manipulations. Seven days after surgery all rabbits again underwent relaparotomy via a paramedian incision to evaluate adhesion. Adhesions were designated as fibrinous if they could be pulled apart easily or fibrous if they could not be pulled apart without tearing the serosa. Twelve rabbits in the control group and two rabbits in the treatment group had abdominal adhesions. In conclusion, the study showed that the application of 1% SCMC solution prevented the development of postoperative intraabdominal adhesions.

Keywords: Rabbit, adhesion, sodium carboxymethylcellulose

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