The Effects of Nikethamide and Dyprophylline Combination on Some In Vivo Haemodynamic Parameters


Abstract: In this study, nikethamide (N) and dyprophylline (D), which are thought to improve the possibility of survival and enhance the pharmacodynamic effects on several haemodynamic parameters, were evaluated in respiratory deficient animals. For this purpose, 32 mongrel dogs aged 2-4 years were randomly divided into four equal groups. The drugs were administered intravenously to the dogs, following respiratoric suppression, which was formed by the administration of xylazine-thiopental sodium and restriction of oxygen. Haemodynamic measurements were conducted before, at the time of application (20 mg/kg N, 20 mg/kg D, 20 mg/kg N + 10 mg/kg D and 20 mg/kg N + 20 mg/kg D) and at 5, 15, 30, 45 and 60 min after drug administration. Haemodynamic parameters such as heart rate were monitored by ECG; systolic, diastolic and mean arterial blood pressure were determined by a direct method and cardiac output was determined by the thermodilution technique. Consequently, it was shown that the 20 mg/kg N application was more effective in increasing the heart rate, but its effect on systolic, diastolic and mean arterial blood pressure was found to be insufficient. The combination using 20 mg/kg D supported these effects. Cardiac output was also increased slightly by the combination of N and D.

Keywords: Nikethamide, dyprophylline, haemodynamic parameters, in vivo, dog

Full Text: PDF