Kidney Diseases and Antioxidative Metabolism in Dogs


Abstract: The aim of this study was to investigate the role of free radicals and to show the changes in the antioxidative metabolism of dogs with renal diseases. For this purpose, the plasma malonlydialdehyde levels, activities of the GSH-Px, SOD and CAT in hemolysates of the red cells, and serum and plasma levels of the \beta-carotene and ascorbic acid were analysed to determine their relationships. A total of 35 dogs aged between 3 and 5 years were used. Twenty healthy dogs with no clinical signs comprised the as control group. Clinically, fifteen dogs exhibited kidney disorders and this diagnosis was supported by laboratory measurements of serum total protein, urea and creatinine levels in the trial group. Serum total protein levels were decreased (p<0.001) in dogs with kidney diseases. However, serum urea and creatinine levels were increased in these dogs. Plasma malonlydialdehyde levels of the trial group were significantly higher (p<0.001) than those of the control group. There was no statistical difference (p>0.05) in the levels of \beta-carotene between the trial and control groups. Plasma ascorbic acid levels were decreased (p<0.05) in dogs with kidney diseases. Statistically significant decreases in the GSH-Px (p<0.05), SOD and CAT (p<0.001) enzyme activities were observed in dogs with kidney diseases. In conclusion, the results of this study showed that free radical activities are responsible for the etiology and pathogenesis of kidney diseases in dogs. There was a positive correlation between the intensity of the oxidative stress and the damage and kidney diseases. Therefore, addition of antioxidants to the current classical treatment of kidney diseases in dogs is suggested.

Keywords: Renal diseases, free radicals, antioxidative metabolism, dog.

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