Acute Phase Effect of Trichloroethylene Ingestion on Some Biological Markers in Dogs


Abstract: Trichloroethylene (TE) is an environmental toxic solvent hazardous to human and domestic animals and well known in the industrial sector. The purpose of this study was to determine whether oral TE plays a role in lipid oxidation and tissue damage. Fourteen dogs were treated with an oral toxic dose of 0.5 ml/kg T.E. The acute changes that occurred in creatine kimase (CK), malondialdehyte (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were investigated in blood samples taken before application and 8, 24, 48, 72 and 168 hours after treatment. SOD and GSH-Px activities decreased, protein, albumin and alcalen phosphate did not change and the others increased 8 and 24 h after the TE treatment. Forty-eight hours after the treatment, MDA, CK, albumin and AST increased, while SOD and GSH-Px decreased. All markers returned to their normal levels after 72 h. It was concluded that TE plays a role in oxidative stress and tissue damage in the acute phase. Repeated intake of oral TE can reach serious toxicity in domestic animals living around industial zones polluted with chemicals.

Keywords: trichloroethylene, peroxidation, oxidative stress, environmental, toxic, damage.

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