The Effects of Cyclophosphamide in the Absence and Presence of Mesna on Electrocardiogram in Guinea Pigs


Abstract: This investigation was made to observe the possible cardiotoxic effects of cyclophosphamide on electrocardiogram and whether these could be prevented by mesna or not. In this study, 24 albino male guinea pigs weighing 250-300 g were used and equally divided into 4 groups. The first (control) and second group animals were applied physiologic saline as placebo white the third and fourth group animals were given mesna (21.5 mg/kg) at 0, 180, 360 and 540th minutes intraperitonelly. In addition these, physiologic saline was injected to the first and third group animals whele cyclophosphamide (68,1 mg/kg) was given to the second to the second and fourth group animals at 20th minute intraperitoneally. The heart rates, the amplitudes of P, R and T waves the durations of P, T waves and QRS complex and PR and QT intervals were examined on electrocardiograms belong to lead II. It was observed that the main effects of cyclophosphamide on electrocardiogram were a decrease in the amplitude of R wave, an increase in the duration of T wave and QT interval and finally a decrease in the heart rate. On the other hand, using mesna in the absence and presence of cyclophosphamide did not make any difference on electrocardiographic data.

Keywords: Cardiotoxicity, ECG, cyclophosphamide, mesna

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