Authors: ENVER BEYTUT, BURHAN ÖZBA
Abstract: In this report, congenital lymphoma of B-cell lineage in a Brown Swiss calf is described. A large mass was seen on the head of the calf at birth. At necropsy, multiple masses were found on the skin and internal organs. A histopathological examination showed atypical lymphoid cells separated by connective tissue. None of the tumor cells showed a positive reaction to CD3, but the cells were immunopositive for CD79\alphacy. A CD45+ reaction confirmed a hematopoietic origin of the neoplasm. Tumor cells were also positive for lambda light chain IgG (\lambda IgG). Proliferating cell nuclear antigen (PCNA) immunostaining showed diffuse nuclear positivity. Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining found numerous apoptotic bodies. The neoplasm was diagnosed as a congenital lymphoma of B-cell lineage.
Keywords: B-cell, calf, congenital, lymphoma
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