Postnatal expression pattern of PPAR\gamma gene in pigs


Abstract: PPAR\gamma is a member of the peroxisome proliferator-activated receptor subfamily of nuclear hormone receptors. PPAR\gamma has been showed to be a key regulator of adipocyte differentiation and lipid metabolism. The pattern of PPAR\gamma gene expression in different growth stages and its relation with adipose deposition in pigs is studied. Fifteen female Duroc×Landrace×Yorkshire pigs in 5 groups with 3 pigs in each grup, at live weight of 1, 30, 50, 70, and 90 kg were used to study the developmental gene expression of PPAR\gamma in subcutaneous adipose tissue by means of semi-quantitative RT-PCR. The results showed the PPAR\gamma mRNA levels of porcine adipose tissue increased as pigs grew and deposited fat from 1 to 90 kg live weight (P < 0.05). The present data indicated a close positive correlation between the levels of PPAR\gamma gene expression and the fat deposition rate in pigs. The experiment showed the total adipose weight increased significantly with body weight (P < 0.05).

Keywords: PPAR\gamma, gene expression, fat deposition, pigs

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