Authors: AHMAD REZA MASSAH, MINA DABAGH, MARYAM AFSHAR, AHMAD REZA MOMENI, HAMID ALIYAN, HAMID JAVAHERIAN NAGHASH
Abstract: Reaction of sulfonamides with carboxylic acid anhydrides and chlorides in the presence of silica phosphoric acid provided N-acyl sulfonamides in good to high yields. All reactions were performed under mild conditions in solvent-free and heterogeneous systems and the products were obtained in high purity after a simple work-up. Silica phosphoric acid could be reused for 3 times without visible loss of activity.
Keywords: N-acylsulfonamide, solvent-free, silica phosphoric acid, heterogeneous condition, N-acylation
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