Authors: YASEMİN DÜNDAR, BİLGE ÇAKIR, ESRA KÜPELİ, M. FETHİ ŞAHİN, NİNGUR NOYANALPAN
Abstract: We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4- substituted-thiosemicarbazides and their corresponding cyclized 3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione ana-logs in which position 4 of the triazole ring was substituted by cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl, p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals. None of the compounds, except 5a, 5e, and 5h, caused gastric lesions or bleeding. Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds.
Keywords: 2-Benzothiazolinone, thiosemicarbazide, 1,2,4-triazol-5-thione, analgesic and anti-inflammatory activity
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