Authors: KEMAL SANCAK, YASEMİN ÜNVER, MUSTAFA ER
Abstract: 2-Amino-1,3,4-thiadiazoles compounds (2a-e) were obtained from the reaction of thiosemi carbazide with 2-cyanomethoxyphenoxyacetonitriles (1). Mono acylamino, mono aroylamino and diethoxycarbonyl imino-1,3,4-thiadiazole compounds (3a-e, 4a-e, 5a-c) were synthesized via the reaction of 2-amino-1,3,4-thiadiazole compounds (2a-e) with acetyl chloride or acetic anhydride, benzoyl chloride or benzoic anhydride and ethyl chloroformate, respectively. The in vitro antitumor activities of some selected compounds were screened and compounds 2a, 2b, 2c, 3a, 3b, 3c, 5a, 5b and 5c were found to be active.
Keywords: 1,3,4-Thiadiazole, acetyl chloride, benzoyl chloride, ethyl chloro formate, antitumor activity
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