The Atomic Absorption Spectrophotometric Method for Indirect Determination of Nimodipine in Tablets


Abstract: A simple indirect atomic absorption spectrophotometric (AAS) method is described for the analysis of nimodipine in tablet formulations. The method is based on the reduction of the antihypertensive drug substances including an aromatic nitro group by boiling them with cadmium metal in 0.05 N HC??l medium under CO_2 atmosphere for 1 h under reflux. The amounts of the drugs were calculated by determining the atomic absorbances of the released Cd^{+2}. The calibration graphs were plotted between the absorbance Cd^{+2} concentrations in the range of 0.242 to 1.209 \mu^{-3} for nimodipine. As a reference method, the spectrophotometric procedure was developed. The 2 methods developed were applied to the assay of nimodipine in commercial tablet formulations, and a statistical comparison of the results with those obtained from the reference method showed good agreement. The method has the advantage of being simple, inexpensive, and easy to perform.

Keywords: Aromatic nitro compounds, Cadmium ion, Pharmaceutical analysis, Indirect determination

Full Text: PDF