Authors: TİJEN ÖNKOL, BİLGE ÇAKIR, M. FETHİ ŞAHİN, ENGİN YILDIRIM, KEVSER EROL
Abstract: Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and ^1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.
Keywords: 2-Oxobenzothiazoline, 1,3,4-thiadiazole, antinociceptive activity
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