Synthesis of 2,4-Dihydro-4-(2-phenylethyl)-5-(isomeric pyridyl)-3H-1,2,4-triazole-3-thiones and Their Derivatives.

Authors: Rashid IQBAL, Khosrow ZAMANI, Nasim H. RAMA

Abstract: Intramolecular cyclization of the three isomeric 1,4-disubstituted thiosemicarbazides 3(a-c) in aqueous sodium hydroxide was attempted to obtain 2,4-dihydro-4-(2-phenylethyl)-5-(isomeric pyridyl)- 3H-1,2,4-triazole-3-thiones 4(a-c). Each of the three isolated triazoles was separately treated with benzyl chloride and with chloroacetic acid to furnish the corresponding benzylthio 5(a-c) and carboxymethylthio derivatives 6(a-c), respectively


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