Voltammetric Determination of Salbutamol Based on Electrochemical Oxidation at Platinum and Glassy Carbon Electrodes

Authors: Niyazi YILMAZ, Sibel A. ÖZKAN, Bengi USLU, Zühre ŞENTÜRK, İnci BİRYOL

Abstract: The oxidative behavior of salbutamol was studied as a function of pH at platinum and activated glassy carbon electrodes. Between pH 1.9 and 12.0, the drug was characterized by a single oxidation step at both electrodes. The process was found to be dependent on the nature and the pH of the supporting elctrolyte. The procedure yielded a linear concentration range of $1 \times 10^{-4}$ to $1 \times 10^{-3}$ M and $2 \times 10^{-5}$ to $1 \times 10^{-3}$ M in 0.2 M sulphuric acid and a phosphate buffer of pH 6, at platinum and glassy carbon electrodes, respectively. The method was used for the determination of salbutamol in pharmaceutical dosage forms. Keywords: Salbutamol, platinum and glassy carbon electrodes, pharmaceutical dosage forms, voltammetry.


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