Synthesis, spectral characterisation, electrochemical, and fluorescence studies of biologically active novel Schiff base complexes derived from E-4-(2-hydroxy-3-methoxybenzlideneamino)-N-(pyrimidin-2-yl)benzenesulfonamide


Abstract: A new Schiff base was prepared from 2-sulphanilamidopyrimidine and 2-hydroxy-3-methoxybenzaldehyde in ethanolic media and it was complexed with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions. The synthesised ligand and complexes were characterised by IR, UV, ^1H and ^{13}C NMR, elemental analysis, cyclic voltammetry, EPR, molar conductance, and magnetic susceptibility. The reasonable shifts in FT-IR and NMR spectral signals of the complexes with respect to the free ligand confirm good coordination of the Schiff-base ligand with the metal through imine nitrogen and oxygen atoms of Schiff base moiety. The Schiff-base ligand and the complexes were screened for antimicrobial activity and fluorescent behaviour. From the analytical and spectral data, the stoichiometry was found to be 1:2 for all the complexes. An octahedral structure was proposed. All the complexes were found to be active against bacteria and fungi.

Keywords: Schiff base, 2-sulphanilamidopyrimidine, 2-hydroxy-3-methoxybenzaldehyde, metal complexes, biological activity, fluorescent behaviour

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