Authors: PERUZE AYHAN EŞİYOK, ÖZLEM SEVEN, GÜLÜZAR EYMUR, GAMZE BORA TATAR, DİDEM DAYANGAÇ ERDEN, KEMAL YELEKÇİ, HAYAT YURTER, AYHAN SITKI DEMİR
Abstract: New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
Keywords: Histone deacetylase inhibition activity, aryl butenoic acid derivatives, molecular docking
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