Authors: TIANHUA SHEN, QUAN QIN, HANG NI, TING XIA, XIAOCONG ZHOU, FUNA CUI, JUNQI LI, DEQIANG RAN, QINGBAO SONG
Abstract: The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.
Keywords: Chiral amino alcohol, copper(I) salt, asymmetric catalysis, Henry reaction
Full Text: PDF