Authors: VITALIY SVIRIPA, MICHAEL D. CONROY, WEN ZHANG, ALICE LIU, DAVID S. WATT
Abstract: Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.
Keywords: Adenosine monophosphate-activated kinase, biotinylated N,N'-diarylureas
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