Authors: SULTAN BAYTAŞ, NAZAN İNCELER, KHATEREH FATTAHPOUR MAVANEH, MECİT ORHAN ULUDAĞ, NURETTİN ABACIOĞLU, MEHTAP GÖKÇE
Abstract: Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.
Keywords: Hybrid, antipyrine, pyridazinone, writhing, carrageenan
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