Authors: MOHSEN VALIZADEH HOLAGH, ABEL MOHAMMADALI OGLU MAHARRAMOV, MIRZA ALIAKBAR OGLU ALLAHVERDIYEV, ALI RAMAZANI, YAVAR AHMADI, FATEMEH ZEINALI NASRABADI, ALI SOULDOZI
Abstract: Reactions of N-isocyaniminotriphenylphosphorane with 2-oxopropyl benzoate (or 2-oxopropyl 4-bromobenzoate) in the presence of 3-phenyl-2-propynoic acid and primary amines proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed.
Keywords: 2-Oxopropyl benzoate, 2-oxopropyl 4-bromobenzoate, 3-phenyl-2-propynoic acid, 1,3,4-oxadiazole, N-isocyaniminotriphenylphosphorane
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