Authors: JAVAD SAFAEI GHOMI, FARIBA SALIMI, ALI RAMAZANI, FATEMEH ZEINALI NASRABADI, YAVAR AHMADI
Abstract: A 3-component domino reaction approach between a primary amine, a dialkyl acetylenedicarboxylate, and 2-oxo-2- phenylacetaldehyde that affords novel alkyl 2-benzoyl-4-alkylamino- 5-oxo-2,5-dihydro-3-furan carboxylate derivatives is reported. The reaction sequence consists of an initial Michael addition of primary amines to dialkyl acetylenedicarboxylates, followed by an aldol-like reaction with 2-oxo-2-phenylacetaldehyde, and then \gamma -lactonization to afford the products. This cascade reaction sequence represents a rapid and unprecedented route to the described biologically interesting molecules.
Keywords: Dialkyl acetylenedicarboxylates, 2-oxo-2-phenylacetaldehyde, primary amines, furan, Michael addition
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