Authors: ASAL FALLAH-TAFTI, TAHMINEH AKBARZADEH, PARASTOO SANIEE, FARIDEH SIAVOSHI, ABBAS SHAFIEE, ALIREZA FOROUMADI
Abstract: A series of [(4-nitro-1H-imidazol-1-yl)methyl]-1,2,4- triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their activity against sensitive and resistant H. pylori strains. Study of the structure-activity relationship of these series of compounds indicated that the type of nitroimidazole moiety and the pendent group on the heteroaryl analog dramatically impact the anti-H. pylori activity. In triazole series, compound 5d, containing a 4-methyl phenyl group on the triazole ring, was the most potent compound tested against both metronidazole-sensitive and -resistant strains at a concentration of 8 \mu g.
Keywords: 4-Nitroimidazole, 1,2,4-triazoles, 1,3,4-thiadiazoles, 1,3,4-oxadiazoles, anti-H. pylori activity
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