Authors: OYA ÜNSAL TAN, KERİMAN ÖZADALI, ÖZGÜR YEŞİLYURT, HAKAN KAYIR, İSMAİL TAYFUN UZBAY, AYLA BALKAN
Abstract: Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
Keywords: Isoxazolo[4,5-d]pyridazin-4(5H)-one, hot-plate test, writhing test, analgesic effect
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